In Silico Prediction of Peroxisomal Proteins in Mouse

Peroxisomes are small vesicle-like subcellular respiratory organelles present in virtually all eukaryotic cells. Peroxisomes are involved in lipid metabolism, such as β-oxidation of fatty acids, synthesis of sterols and bile acids and also in glyoxylate metabolism and gluconeogenesis [3]. The importance of peroxisomes is underscored by the existence in human of a group of serious metabolic disorders caused either by impairment of peroxisome biogenesis or by defects of individual peroxisomal enzymes. Despite the fact that peroxisomes were first discovered in the 1960s, the functions performed by these organelles are still not fully understood. Identification of all peroxisome components will aid in our understanding of peroxisome biology and discovery of molecular targets to treat disorders associated with this organelle.